abstract：:Severe congenital neutropenia (SCN) is characterized by a maturation arrest of myeloid progenitor cells at the stage of promyelocytes in bone marrow and low levels of mature neutrophils in peripheral blood. To date, little is known regarding the underlying pathomechanism of SCN. A defective response of neutrophil prec...

journal_title：International journal of hematology

authors： Kasper B,Tidow N,Welte K

更新日期：1999-12-01 00:00:00

abstract：:We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

journal_title：International journal of hematology

authors： Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

更新日期：1999-10-01 00:00:00

abstract：:In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...

journal_title：International journal of hematology

authors： Peters SO,Habibian HK,Vergilis K,Quesenberry PJ

更新日期：1999-08-01 00:00:00

abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

journal_title：International journal of hematology

authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

更新日期：1999-07-01 00:00:00

abstract：:Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...

journal_title：International journal of hematology

authors： Nakahara Y,Suzuki H,Ohashi H,Hatano S,Tomita A,Kinoshita T,Murate T,Saito H,Hotta T

更新日期：1999-06-01 00:00:00

abstract：:The survival, proliferation, and differentiation of hematopoietic cells are regulated by cytokines. In the absence of cytokines, hematopoietic cells not only stop proliferation, but undergo apoptosis. This strict dependency of hematopoietic cells on cytokines is an important mechanism that maintains the homeostasis of...

journal_title：International journal of hematology

authors： Miyajima A,Ito Y,Kinoshita T

更新日期：1999-04-01 00:00:00

abstract：:We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reactio...

journal_title：International journal of hematology

authors： Sue YC,Liu TC,Chang CS,Huang SM,Chen TP,Lin SF

更新日期：1999-04-01 00:00:00

abstract：:We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

journal_title：International journal of hematology

authors： Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

更新日期：1999-02-01 00:00:00

abstract：:We established a simple method of T cell depletion using anti-CD6 monoclonal antibody-conjugated immunomagnetic beads. Preliminary experiments using this method demonstrated that CD3+ T cells could be partially depleted without depleting CD56+ NK cells. A phase I-II clinical study was performed to assess the safety an...

journal_title：International journal of hematology

authors： Sao H,Kitaori K,Kasai M,Shimokawa T,Kato C,Yamanishi H,Ueda R,Morishima Y

更新日期：1999-01-01 00:00:00

abstract：:Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...

journal_title：International journal of hematology

authors： Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil S

更新日期：1998-12-01 00:00:00

abstract：:Rh blood group antigens are associated with non-glycosylated human erythrocyte membrane proteins encoded by two closely related genes, RHCE and RHD, and with a glycoprotein, a critical co-expressing factor encoded by the RH50 gene. The sequence analysis of RHCE transcripts has revealed that RhE/e and C/c serological p...

journal_title：International journal of hematology

authors： Iwamoto S,Yamasaki M,Kawano M,Okuda H,Omi T,Takahashi J,Tani Y,Omine M,Kajii E

更新日期：1998-10-01 00:00:00

abstract：:We investigated the effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa-tissue factor activity by antithrombin III (ATIII) on a human bladder carcinoma (J82) cell line and an ovarian carcinoma (OC-2008) cell line, two tumor cell lines which constitutively synthesize and express high lev...

journal_title：International journal of hematology

authors： Hamamoto T,Kisiel W

更新日期：1998-07-01 00:00:00

abstract：:Thy-1 (CDw90) is a phosphatidylinositol-anchored protein, and is expressed on human pluripotential hematopoietic stem cells. The expression pattern of this antigen on leukemia cells is still controversial. In this study, 72 adult patients with pre-B cell acute lymphoblastic leukemia (pre-B ALL) were examined for the e...

journal_title：International journal of hematology

authors： Takahashi T,Mizutani M,Miwa H,Katayama N,Nishii K,Shikami M,Yamaguchi M,Shiku H,Kamada N,Kita K

更新日期：1998-06-01 00:00:00

abstract：:We established two novel cell lines, designated as IMS-BC1 and IMS-BC2, from two patients with chronic myelogenous leukemia in blast crisis. The two cell lines were positive for CD13 and CD33 and negative for CD34 and HLA-DR by surface marker analysis. IMS-BC1 had four Philadelphia (Ph1) chromosomes and a breakpoint w...

journal_title：International journal of hematology

authors： Nagamura F,Nagamura-Inoue T,Tojo A,Minamihisamatsu M,Tanabe T,Zaike Y,Tani K,Saisho H,Asano S

更新日期：1998-04-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00

abstract：:Pluripotent stem cells of hematopoiesis are included among CD34+ cells in the blood and bone marrow. After granulocyte-colony stimulating factor (G-CSF) mobilization, 1-2% of the mononuclear cells in the blood are CD34+ cells, which can be obtained by leukapheresis. We performed CD34+ progenitor cell transplantation i...

journal_title：International journal of hematology

authors： Yasui M,Park YD,Okamura T,Chayama K,Yoshimoto T,Inoue M,Yagi K,Kawa K

更新日期：1998-01-01 00:00:00

abstract：:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of th...

journal_title：International journal of hematology

authors： Aïdoudi S,Lebeurier I,Amiral J,Quentin G,Caen JP,Han ZC

更新日期：1997-12-01 00:00:00

abstract：:Immunological abnormalities (IA) are frequently observed in patients with myelodysplastic syndromes (MDS). Although there have been a number of analyses of the prognostic factors, there have been few studies, if any, to determine whether IA affects prognosis. We investigated the prognosis of 153 MDS patients with or w...

journal_title：International journal of hematology

authors： Okamoto T,Okada M,Mori A,Saheki K,Takatsuka H,Wada H,Tamura A,Fujimori Y,Takemoto Y,Kanamaru A,Kakishita E

更新日期：1997-10-01 00:00:00

abstract：:The 12- to 14-kDa eosinophil major basic protein (MBP) is primarily translated as 25-kDa pro-MBP. HL-60, a promyelocytic leukemia cell line, produces pro-MBP but not MBP, suggesting production of pro-MBP by immature granulocytes. We measured the serum levels of total MBP, using an ELISA that detects both pro-MBP and M...

journal_title：International journal of hematology

authors： Mukai HY,Ninomiya H,Nagasawa T,Abe T

更新日期：1997-08-01 00:00:00

abstract：:Neutropenic enterocolitis is a frequent autopsy finding in adult patients with acute leukemias. The predisposing factors other than neutropenia are not clear. There are also contradictions about treatment. Therefore, this entity still presents a diagnostic and therapeutic dilemma for clinicians. This retrospective stu...

journal_title：International journal of hematology

authors： Büyükaşik Y,Ozcebe OI,Haznedaroğlu IC,Sayinalp N,Soylu AR,Ozdemir O,Dündar S

更新日期：1997-07-01 00:00:00

abstract：:Waldenstroem's macroglobulinemia is usually closely related to a histopathologic subtype called lymphoplasmacytoid lymphoma in the Revised European-American Lymphoma (REAL) classification. Here, we report a case of B-cell lymphoma accompanied by monoclonal macroglobulinemia and pathologically compatible with marginal ...

journal_title：International journal of hematology

authors： Nakata M,Matsuno Y,Takenaka T,Kobayashi Y,Takeyama K,Yokozawa T,Tobinai K

更新日期：1997-06-01 00:00:00

abstract：:The plasma levels of soluble urokinase-type plasminogen activator receptor (uPAR; CD87) measured by enzyme-linked immunosorbent assay were higher in patients with paroxysmal nocturnal hemoglobinuria (PNH) (5.8 +/- 4.7 ng/ml, mean +/- S.D., n = 9) than in normal donors (2.0 +/- 0.8 ng/ml, mean +/- S.D., n = 15). The hi...

journal_title：International journal of hematology

authors： Ninomiya H,Hasegawa Y,Nagasawa T,Abe T

更新日期：1997-04-01 00:00:00

abstract：:A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

journal_title：International journal of hematology

authors： Kondo H,Date Y

更新日期：1997-02-01 00:00:00

abstract：:We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...

journal_title：International journal of hematology

authors： Nakano T

更新日期：1996-12-01 00:00:00

abstract：:Initial treatment with androgen (metenolone acetate) alone for 19 weeks had no effect in a 45-year-old Japanese female with refractory anemia (RA). The patient achieved trilineage hematologic recovery after addition of recombinant human granulocyte colony-stimulating factor (G-CSF) and recombinant human erythropoietin...

journal_title：International journal of hematology

authors： Katayama Y,Kojima K,Omoto E,Harada M

更新日期：1996-12-01 00:00:00

abstract：:We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

journal_title：International journal of hematology

authors： Imagawa S,Yamamoto M,Ueda M,Miura Y

更新日期：1996-10-01 00:00:00

abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

journal_title：International journal of hematology

authors： Yano K,Iijima K,Sao H,Kobayashi M

更新日期：1996-10-01 00:00:00

abstract：:The changes of the FVIII binding capacity of vWF after the infusion of FVIII/vWF concentrate was studied in two patients with type 2N vWD, and also during pregnancy in one of them. After infusion of FVIII or DDAVP to the patients, FVIII:C in plasma increased as expected, but it then decreased, with a markedly short ha...

journal_title：International journal of hematology

authors： Nishino M,Nishino S,Sugimoto M,Shibata M,Tsuji S,Yoshioka A

更新日期：1996-08-01 00:00:00

abstract：:Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...

journal_title：International journal of hematology

authors： Perry AR,Pagliuca A,Fitzsimons EJ,Mufti GJ,Williams R

更新日期：1996-07-01 00:00:00

abstract：:The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokin...

journal_title：International journal of hematology

authors： Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

更新日期：1996-06-01 00:00:00

abstract：:The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...

journal_title：International journal of hematology

authors： Mitani K

更新日期：1996-02-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

journal_title：International journal of hematology

authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

更新日期：1995-10-01 00:00:00

abstract：:We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

journal_title：International journal of hematology

authors： Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

更新日期：1995-06-01 00:00:00

abstract：:Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...

journal_title：International journal of hematology

authors： el-Sonbaty SS,Watanabe M,Hochito K,Yamaguchi K,Matsuda I,Tsuchiya H

更新日期：1995-02-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

journal_title：International journal of hematology

authors： Nimer SD,Leung DH,Wolin MJ,Golde DW

更新日期：1994-10-01 00:00:00

abstract：:We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...

journal_title：International journal of hematology

authors： Iwabuchi A,Ohyashiki K,Ohyashiki JH,Kimura Y,Lin KY,Aizawa S,Nehashi Y,Miyazawa K,Yaguchi M,Toyama K

更新日期：1994-10-01 00:00:00

abstract：:Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

journal_title：International journal of hematology

authors： Yokose N,Ogata K,Dan K,Nomura T

更新日期：1994-08-01 00:00:00

abstract：:Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...

journal_title：International journal of hematology

authors： Yoshida Y,Ichinoe T,Dodo M,Noukawa M,Maeda A,Oguma S,Tajima M,Yamamoto K,Okuma M

更新日期：1994-07-01 00:00:00